Real-time Measurement of Cellular Refractive Index and Thickness Using Cell Culture Chip
نویسندگان
چکیده
This paper reports the measurement of refractive index (RI) and thickness of living cells using cell culture chip integrated with micro-indicators via immersion refractometry. In the experiment, the RI and the thickness of the cultured MadinDarby canine kidney (MDCK) cell line are obtained simultaneously. As this method features high accuracy, no damage to a group of the living cells and real time measurement during long-term cell culture, it is promising for many applications such as detecting pathological changes of cells and cancer cell detection.
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